Center for Hormone Advanced Science and Education (CHASE)
Welcome to the Center for Hormone Advanced Science and Education (CHASE) website! The CHASE at the Roskamp Institute, headed by Dr. Rena Li, is a multidisciplinary research center devoted to the study of hormones and their use in the treatment of neurological disorders, mental illnesses, heart disease and bone loss. The CHASE promotes basic, translational, and clinical research and education on endocrinology in neuroscience, particularly on the roles of sex hormones in healthy and aging brain function. The scope of research activities at the CHASE is broad and translational, ranging from analysis of genetic influences to potential therapeutic compounds and clinical treatments of patients with hormone related diseases. The current projects in CHASE are funded by National Institute of health (NIH), the American Health Assistance Foundation (AHAF), the Alzheimer's Association and other resources. Our missions are to develop alternative medicines to help affected individuals with better and safer natural products.
CHASE also promotes education on the role of hormones in healthy aging by relaying the advances in molecular and biochemical basic research to the public. Enhancing awareness of the importance of hormone balance throughout the life span is a key function of CHASE. The other equally important object of CHASE is the training of postdoctoral and medical fellows, graduate and medical students in neuroendocrinology with frontier knowledge and cutting-edge research technologies. CHASE welcomes trainees from diversified disciplines including molecular biology, cell biology, genetics, pharmacology, neurology, psychiatry, obstetrics & gynecology, orthopedics, and herbal medicines etc.
For open positions at this center please visit our careers website.
Cheng X, He P, Yao H, Dong Q, Li R, Shen Y.
(2014) Occludin Deficiency with BACE1 Elevation in Cerebral Amyloid
Angiopathy. Neurology. May 13. [Epub ahead of print]
Li R, Cui J, Shen Y. (2014) Brain Sex Matters: estrogen in
cognition and Alzheimer's disease. Molecular and Cellular
Endocrinology. Jan 11 [Epub ahead of print]
Li R, Singh M.
(2014) Sex differences in cognitive impairment and Alzheimer's
disease. Frontiers in Neuroendocrinology. 2014 Jan 13 [Epub ahead of
Cheng X, He P, Lee T, Yao
H, Li R, Shen Y. (2014) High activities of BACE1 in brains with mild
cognitive impairment. American Journal of Pathology.184:1-7
Cui J, Jothishankar B, He P, Staufenbiel M, Shen Y, Li R. (2014)
Amyloid precursor protein mutation disrupts reproductive
experience-enhanced normal cognitive development in a mouse model of
Alzheimer's disease. Molecular Neurobiology. 49(1)103-112
Shen Y, Yang LB, Li R. (2013) What does complement do in Alzheimer's
disease? Old molecules with new insights. Translational
Wu Y, Ding J, Gao Y, Chen S, Li
L, Li R. (2013) Mini review: Linkages between essential tremor and
Parkinson’s disease? Frontiers in Cellular Neuroscience. Jul
Shen Y. (2013) An old method facing a new challenge: re-visiting
housekeeping protein as internal reference control for neuroscience
research. Life Science. 92(13):747-751.
Wang H, Li R, Shen
Y*. (2013) Beta-secretase: its biology as a therapeutic target in
diseases. Trends in Pharmacological Science. 34(4):215-25
P, Li P, Hua Q, Liu Y, Staufenbiel M, Li R, Shen Y*. (2013) Chronic
administration of anti-stroke herbal medicine TongLuoJiuNao reduces
abnormal processing of amyloid precursor protein in a mouse model of
Alzheimer's disease. PLoS ONE. 8(3):e58181
He P, Cheng X,
Staufenbiel M, Li R, Shen Y*. (2013) Long-term treatment of
thalidomide ameliorates amyloid-like pathology through Inhibition of
beta-secretase in a mouse model of Alzheimer's disease. PLoS ONE.
Cui J, Shen Y, Li R*. (2013) Estrogen synthesis and signaling pathways during ageing: from periphery to brain.
Trends in Molecular Medicine. 19(3): 197-209 (IF= 10.5)
Li R*, Cui J, Jothishankar B, Shen J, He P, Shen Y. (2013) Early reproductive experiences in females make differences in cognitive function later in life.
Journal of Alzheimer's Disease. 34: 589-594
Li R*, He P, Cui J, Staufenbiel M, Harada N, Shen Y. (2013) Brain endogenous estrogen levels determine responses to estrogen replacement therapy via regulation of BACE1 and NEP in female Alzheimer's transgenic mice.
Molecular Neurobiology. 47(3): 857-867
Jiang H, He P, Adler CH, Shill H, Beach TG, Li R, Shen Y*.(2012) Bid signal pathway components are identified in the temporal cortex with Parkinson disease. Neurology. 23;79(17):1767-73. (IF=8.0)
Long J, He P, Shen Y, Li R*. (2012) New evidence of mitochondria dysfunction in the female Alzheimer's brain: deficiency of estrogen receptor-beta. Journal of Alzheimer's Disease. 30(3):545-58. (IF=3.7)
Jiang H, Hampel H, Prvulovic D, Wallin A, Blennow K, Li R, Shen Y*. (2011) Elevated CSF level of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease. Molecular Neurodegeneration, 6(1): 69 (IF=4.2)
Li R*, Staufenbiel M, Shen Y. (2011) Effect of different estrogens on BACE in Alzheimer's disease. Alzheimer's & Dementia 7:S464-S465 (IF 6.3)
McAllister C, Long J, Bowers A, Walker A, Cao P, Honda S-I, Harada N, Staufenbiel M , Shen Y, Li R*. (2010) Genetic targeting aromatase in male amyloid precursor protein (APP) transgenic mice down-regulates beta-secretase (BACE1) and prevents Alzheimer-like pathology and cognitive impairment. Journal of Neuroscience, 30: 7326-7334 (IF=7.1)
Cheng X., Yang L., He P, Li R., Shen Y*. (2010) Differential activation of TNF receptors distinguishes Alzheimer from normal brains. Journal of Alzheimer's Disease, 19(2):621-30. (IF=3.7)
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"We have assembled a fantastic team of scientists
and clinicians here at the Roskamp Institute." –
Dr. Fiona Crawford